BIRC8 Antibody - BSA Free

Images

 
Western Blot: BIRC8 Antibody [NBP1-76669] - Human HepG2 (lane 1) and MOLT4 (lane 2) cell lysates with ILP-2 antibody at 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: BIRC8 Antibody [NBP1-76669] - Immunofluorescence of ILP-2 in HepG2 cells with ILP-2 antibody at 20 ug/mL.
Immunocytochemistry/ Immunofluorescence: BIRC8 Antibody [NBP1-76669] - HepG2 cells with BIRC8 antibody at 10 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

Order Details

BIRC8 Antibody - BSA Free Summary

Immunogen
Antibody was raised with against a synthetic peptide corresponding to amino acids near the amino terminus of human ILP-2. The immunogen is located within the first 50 amino acids of ILP-2. Amino Acid Squence: TGYEARLITFGT
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BIRC8
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 10-20 ug/ml
  • Western Blot 1 ug/ml
Application Notes
A band at approximately 33 kDa can be detected in Western Blot.
Theoretical MW
33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
BIRC8 Peptide (NBP1-76669PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for BIRC8 Antibody - BSA Free

  • baculoviral IAP repeat containing 8
  • baculoviral IAP repeat-containing 8
  • baculoviral IAP repeat-containing protein 8
  • BIRC8
  • hILP2
  • IAP-like protein 2
  • ILP2
  • ILP-2ILP2
  • Inhibitor of apoptosis-like protein 2
  • RNF136
  • Testis-specific inhibitor of apoptosis

Background

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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The Ins and Outs of Survivin
By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ...  Read full blog post.

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Bioinformatics

Gene Symbol BIRC8
Uniprot