BIRC8 Products

Description

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Bioinformatics

Entrez	112401 Human
Uniprot	Q96P09 Human NP_203127 Human AAH39318 Human AAH39318.1 Human
Product By Gene ID	112401
Alternate Names	Inhibitor of apoptosis-like protein 2 baculoviral IAP repeat-containing protein 8 hILP2 IAP-like protein 2 baculoviral IAP repeat-containing 8 ILP-2ILP2 Testis-specific inhibitor of apoptosis baculoviral IAP repeat containing 8

Diseases related to BIRC8

Discover more about diseases related to BIRC8.

Leukemia, Myelocytic, Acute
Leukemia
Neuroblastoma
Hematologic Neoplasms
Cell Transformation, Neoplastic
Hereditary Hemorrhagic Telangiectasia
B-cell Lymphomas
Acute Lymphocytic Leukemia
Acute Kidney Injury
Brain Neoplasms
Carcinogenesis
Injury To Kidney
Malignant Neoplasms
Neoplasms
Myeloid Leukemia
Diffuse Large B-cell Lymphoma
Severe Combined Immunodeficiency
Lymphoma
Lymphoid Leukemia
Acute Interstitial Pneumonia

Pathways for BIRC8

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Cell Death
Cell Division
Programmed Cell Death
Induction Of Apoptosis
Tissue Homeostasis
Oncogenesis

Research Areas for BIRC8

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Apoptosis
Cancer
Tumor Suppressors
Zinc Finger

Bioinformatics Tool for BIRC8

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