BIRC8 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	112401
Alternate Names	baculoviral IAP repeat containing 8 baculoviral IAP repeat-containing 8 baculoviral IAP repeat-containing protein 8 BIRC8 hILP2 IAP-like protein 2 ILP2 ILP-2ILP2 Inhibitor of apoptosis-like protein 2 RNF136 Testis-specific inhibitor of apoptosis

Research Areas for BIRC8

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors
Zinc Finger

Related BIRC8 Blog Posts

Check out the latest blog posts on BIRC8.

The Ins and Outs of Survivin By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ...    Read more.

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