BIRC8 Products

Description

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Bioinformatics

Entrez	112401 Human
Uniprot	AAH39318 Human AAH39318.1 Human NP_203127 Human Q96P09 Human
Product By Gene ID	112401
Alternate Names	baculoviral IAP repeat containing 8 baculoviral IAP repeat-containing 8 baculoviral IAP repeat-containing protein 8 hILP2 IAP-like protein 2 ILP-2ILP2 Inhibitor of apoptosis-like protein 2 Testis-specific inhibitor of apoptosis

Diseases related to BIRC8

Discover more about diseases related to BIRC8.

Leukemia, Myelocytic, Acute
Leukemia
Neuroblastoma
Hematologic Neoplasms
Cell Transformation, Neoplastic
Hereditary Hemorrhagic Telangiectasia
B-cell Lymphomas
Acute Lymphocytic Leukemia
Acute Kidney Injury
Brain Neoplasms
Carcinogenesis
Injury To Kidney
Malignant Neoplasms
Neoplasms
Myeloid Leukemia
Diffuse Large B-cell Lymphoma
Severe Combined Immunodeficiency
Lymphoma
Lymphoid Leukemia
Acute Interstitial Pneumonia

Pathways for BIRC8

View related products by pathway and learn more about each of the pathways below.

Cell Death
Cell Division
Programmed Cell Death
Induction Of Apoptosis
Tissue Homeostasis
Oncogenesis

Research Areas for BIRC8

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Apoptosis
Cancer
Tumor Suppressors
Zinc Finger

Bioinformatics Tool for BIRC8

Discover related pathways, diseases and genes to BIRC8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related BIRC8 Blog Posts

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The Ins and Outs of Survivin By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of ...    Read more.

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