beta I Tubulin Antibody (923425) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clone: 923425
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

beta I Tubulin Antibody (923425) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human β-I Tubulin
  Met1-His451
  Accession # Q9H4B7
• Specificity: Detects human beta -I Tubulin in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for beta I Tubulin Antibody (923425) [Alexa Fluor® 750]

• beta tubulin 1, class VI
• betaI Tubulin
• beta-I Tubulin
• dJ543J19.4
• TUBB1
• tubulin beta-1 chain
• tubulin, beta 1

Background

beta -tubulin is a 50 kDa cytoskeletal protein which is the a major component of neuronal processes: axons, dendrites, and dendritic spines. beta -tubulin is represented by different isoforms including beta -I, beta -II, beta -III, and beta -IV. Elimination of beta -I isoform will decrease the viability of neuroblastoma cells. Formation of actin tubules may be directly inhibited by beta -I isoform which results in decreasing cellular adhesion. beta -I Tubulin levels in different brain regions of schizophrenia patients  undergo noticeable changes suggesting that this isoform may have a specific role in the pathophysiology of this illness by affecting actin tubule formation which is required for cell division and differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.