Reactivity | HuSpecies Glossary |
Applications | WB, Simple Western |
Clonality | Polyclonal |
Host | Sheep |
Conjugate | Unconjugated |
Concentration | LYOPH |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human beta ‑Glucuronidase/GUSB Met1-Thr651 Accession # AAA52561 |
Specificity | Detects human beta ‑Glucuronidase/GUSB in direct ELISAs and Western blots.
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Source | N/A |
Isotype | IgG |
Clonality | Polyclonal |
Host | Sheep |
Gene | GUSB |
Purity | Immunogen affinity purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Publications |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Concentration | LYOPH |
Purity | Immunogen affinity purified |
Reconstitution Instructions | Sterile PBS to a final concentration of 0.2 mg/mL. |
Human beta -Glucuronidase (EC 3.2.1.31) encoded by the GUSB gene is a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans that include heparan sulfate, chondroitin sulfate and hyaluronan (1). The enzyme is only active on the glucuronic acid of the non-reducing end. The native protein has been reported as a tetrameric glycoprotein composed of identical subunits (1, 2). Mutations in the GUSB gene are linked to mucopolysaccharidosis type VII (3). Accumulation of partially degraded glycosaminoglycans, with glucuronic acid residues at the non-reducing termini, are usually found in the lysosomes of patients with the disease (3). It has also been reported that this enzyme may contribute to the depletion of chondroitin from cartilage and thereby facilitate the damage of joints in rheumatoid arthritis (4).
Secondary Antibodies |
Isotype Controls |
Diseases for beta-Glucuronidase/GUSB Antibody (AF6144)Discover more about diseases related to beta-Glucuronidase/GUSB Antibody (AF6144).
| Pathways for beta-Glucuronidase/GUSB Antibody (AF6144)View related products by pathway.
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PTMs for beta-Glucuronidase/GUSB Antibody (AF6144)Learn more about PTMs related to beta-Glucuronidase/GUSB Antibody (AF6144).
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