Recombinant Human BCL-W/BCL2L2 Protein

SDS-Page: Human BCL-W/BCL2L2 Protein [NBP2-34895]

• Reactivity: Hu
• Applications: PAGE
• Format: Carrier-Free

Recombinant Human BCL-W/BCL2L2 Protein Summary

• Description: A single non-glycosylated polypeptide chain containing 171 amino acids corresponding to BCL-W/BCL2L2 Source: E. coli

  Uniprot ID: Q92843

  Amino Acid Sequence: ATPASAPDTR ALVADFVGYK LRQKGYVCGA GPGEGPAADP LHQAMRAAGD EFETRFRRTF SDLAAQLHVT PGSAQQRFTQ VSDELFQGGP NWGRLVAFFV FGAALCAESV NKEMEPLVGQ VQEWMVAYLE TQLADWIHSS GGWAEFTALY GDGALEEARR LREGNWASVR T

• Details of Functionality: Test in Process.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: BCL2L2
• Purity: >95%, by SDS-PAGE and HPLC
• Endotoxin Note: Less than 1 EU/ug of BCL-W/BCL2L2 as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 18.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.2 um filtered concentrated solution in 25 mM Hepes, pH 7.4, 100 mM KCl, 10 % Glycerol, 0.02 % Tween-80.
• Preservative: 5% Trehalose
• Purity: >95%, by SDS-PAGE and HPLC

Alternate Names for Recombinant Human BCL-W/BCL2L2 Protein

• Apoptosis regulator Bcl-W
• BCL2L2
• Bcl2-L-2
• BCL2-like 2
• Bclw
• Bcl-w
• BCLWbcl-2-like protein 2
• KIAA0271BCL2-L-2

Background

BCL2L2, also named as Bcl-w, belongs to the Bcl-2 family and is encoded by the BCL2L2 gene in human. BCL2L2 (Bcl-w) is expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands, and moderate levels in thymus, ovary and small intestine. It is also expressed in cell lines of myeloid, fibroblast and epithelial origin. BCL2L2 (Bcl-w) is an anti-apoptotic (pro-survival) protein that reduces cell apoptosis under cytotoxic conditions. Mature human BCL2L2 (Bcl-w) shares 98 % - 99 % amino acid sequence identity with murine, bovine, canine Bcl-w.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for BCL-W/BCL2L2 Recombinant Protein (NBP2-34895)(1)

Publication using NBP2-34895

• Thompson PJ, Shah A, Ntranos V et al. Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes Cell Metab. 2019-02-14 [PMID: 30799288] (Ctrl, Human)

Bioinformatics

• Gene Symbol: BCL2L2
• Uniprot:
  • Q92843()
  • Q92843()
  • Q92843()