BCL-W/BCL2L2 Products

Antibodies
BCL-W/BCL2L2 Antibody [Unconj ...
BCL-W/BCL2L2 Antibody [Unconjugated]
AF824
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
BCL-W/BCL2L2 Antibody
BCL-W/BCL2L2 Antibody
AF8241
Species: Hu, Mu
Applications: IHC
Host: Goat Polyclonal
BCL-W/BCL2L2 Antibody (90316) ...
BCL-W/BCL2L2 Antibody (90316)
MAB824
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
BCL-W/BCL2L2 Overexpression L ...
BCL-W/BCL2L2 Overexpression Lysate...
H00000599-T01
Species: Hu
Applications: WB
BCL-W/BCL2L2 Overexpression L ...
BCL-W/BCL2L2 Overexpression Lysate...
NBL1-07950
Applications: WB
Proteins
Human BCL-W/BCL2L2 Protein
Human BCL-W/BCL2L2 Protein
NBP2-34895
Species: Hu
Applications: Func, PAGE
BCL-W/BCL2L2 Recombinant Prot ...
BCL-W/BCL2L2 Recombinant Protein
NBP1-37073
Species: Hu
Applications: PAGE
RNAi
BCL-W/BCL2L2 RNAi
BCL-W/BCL2L2 RNAi
H00000599-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 599
Alternate Names
  • Bcl2-L-2
  • BCL-W
  • BCLWbcl-2-like protein 2
  • KIAA0271BCL2-L-2
  • Apoptosis regulator Bcl-W
  • BCL2-like 2

Research Areas for BCL-W/BCL2L2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer

PTMs for BCL-W/BCL2L2

Learn more about PTMs related to BCL-W/BCL2L2.

Phosphorylation
Cleavage
Methylation
Dephosphorylation

Bioinformatics Tool for BCL-W/BCL2L2

Discover related pathways, diseases and genes to BCL-W/BCL2L2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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