Bcl-10 Antibody (4F8)

Images

 
Western Blot: Bcl-10 Antibody (4F8) [NBP1-51524] - Western blot analysis using BCL10 mouse mAb against NIH/3T3 (1), Hela (2), MCF-7 (3) and Jurkat (4) cell lysate.
Immunocytochemistry/ Immunofluorescence: Bcl-10 Antibody (4F8) [NBP1-51524] - Confocal immunofluorescence analysis of Hela cells using BCL10 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 ...read more
Immunohistochemistry-Paraffin: Bcl-10 Antibody (4F8) [NBP1-51524] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10 ...read more
Flow Cytometry: Bcl-10 Antibody (4F8) [NBP1-51524] - Flow cytometric analysis of Hela cells using BCL10 mouse mAb (green) and negative control (purple).
Western Blot: Bcl-10 Antibody (4F8) [NBP1-51524] - Western blot analysis using RUNX1 Rabbit pAb against MOT4 (1), Jurkat (2), HepG2 (3), SW620 (4), MCF-7 (5) and PC-2 (6) cell lysate.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC, IHC-P, CyTOF-ready
Clone
4F8
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Bcl-10 Antibody (4F8) Summary

Immunogen
Purified recombinant fragment of human BCL-10 expressed in E. Coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BCL10
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:10000
  • Flow Cytometry 1:200-1:400
  • Immunocytochemistry/Immunofluorescence 1:200-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:200-1:1000
  • CyTOF-ready
Theoretical MW
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP1-51524 in the following applications:

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.03% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Bcl-10 Antibody (4F8)

  • B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10
  • Bcl10
  • Bcl-10
  • CARD-containing apoptotic signaling protein
  • CARD-containing molecule enhancing NF-kappa-B
  • CARD-containing proapoptotic protein
  • CARD-like apoptotic protein
  • CARMEN
  • caspase-recruiting domain-containing protein
  • cCARMEN
  • c-E10
  • c-E10bcl-10
  • CED-3/ICH-1 prodomain homologous E10-like regulator
  • Cellular homolog of vCARMEN
  • cellular-E10
  • CIPER
  • CLAP
  • hCLAP
  • Mammalian CARD-containing adapter molecule E10
  • mE10
  • mE10CARD containing molecule enhancing NF-kB

Background

Bcl-10 is a 31kDa protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Bcl-10 Antibody (NBP1-51524)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA.


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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Bcl-10 Antibody (NBP1-51524) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-51524AF405
Alexa Fluor 488 Labeled NBP1-51524AF488
Alexa Fluor 647 Labeled NBP1-51524AF647
Alexa Fluor 700 Labeled NBP1-51524AF700
Allophycocyanin Labeled NBP1-51524APC
DyLight 350 Labeled NBP1-51524UV
DyLight 405 Labeled NBP1-51524V
DyLight 488 Labeled NBP1-51524G
DyLight 680 Labeled NBP1-51524FR
DyLight 755 Labeled NBP1-51524IR
PE Labeled NBP1-51524PE
PerCP Labeled NBP1-51524PCP

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Bioinformatics

Gene Symbol BCL10
Entrez
Uniprot