BAK Antibody

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Western Blot: Bak Antibody [NB100-94297] - Western blot analysis of Bak in L1210 cell lysates with anti-Bak (NT) at (A) 1 and (B) 2 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

BAK Antibody Summary

Immunogen
Rabbit anti-Bak (NT) polyclonal antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak (GenBank accession no. Q16611).
Specificity
Bak
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
BAK1
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
Application Notes
This polyclonal antibody can be used for detection of Bak by Western blot at 1 to 2 ug/ml. It is human and mouse reactive.
Positive Control
BAK Lysate (NBL1-07909)
BAK Lysate (NBP2-65116)

Reactivity Notes

This antibody is reactive against Human, Mouse

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
IgG purified

Alternate Names for BAK Antibody

  • Apoptosis regulator BAK
  • BAK
  • BAK1
  • BAK-LIKE
  • BAKMGC3887
  • BCL2-antagonist/killer 1
  • BCL2L7
  • bcl2-L-7
  • BCL2L7bcl-2 homologous antagonist/killer
  • BCL2-like 7 protein
  • Bcl-2-like protein 7
  • CDN1
  • MGC117255
  • pro-apoptotic protein BAK

Background

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria (4,5). It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability (6,7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for BAK Antibody (NB100-94297)

Discover related pathways, diseases and genes to BAK Antibody (NB100-94297). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for BAK Antibody (NB100-94297)

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Pathways for BAK Antibody (NB100-94297)

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Research Areas for BAK Antibody (NB100-94297)

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Blogs on BAK.

IRE1 alpha dependent apoptotic-signaling pathway
Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...  Read full blog post.

p53 - Investigating an important tumor suppressor
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...  Read full blog post.

Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis.
Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...  Read full blog post.

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Bioinformatics

Gene Symbol BAK1
Entrez