BAK Products

Antibodies
BAK Antibody
BAK Antibody
NB100-56092
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
BAK Antibody
BAK Antibody
AF816
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
BAK Antibody (564305) [Unconj ...
BAK Antibody (564305) [Unconjugated]
MAB8161
Species: Hu
Applications: WB, ICC
Host: Mouse Monoclonal
Antibody Pairs
BAK Antibody Pair
BAK Antibody Pair
H00000578-PW1
Species: Hu
Applications: WB, IP
Lysates
BAK Overexpression Lysate (Na ...
BAK Overexpression Lysate (Native)
NBL1-07909
Applications: WB
BAK Overexpression Lysate (De ...
BAK Overexpression Lysate (Denatured)
H00000578-T02
Applications: WB
Proteins
BAK Recombinant Protein
BAK Recombinant Protein
H00000578-P01
Species: Hu
Applications: WB, ELISA, PA
BAK Partial Recombinant Prote ...
BAK Partial Recombinant Protein
H00000578-Q01
Species: Hu
Applications: WB, ELISA, PA
BAK Peptide
BAK Peptide
NBP1-77152PEP
Species: Hu
Applications: AC

Description

Bak a pro-apoptotic analog to Bax, is a member of the Bcl-2 family of proteins. During mitochondria-regulated programmed cell death, Bak promotes apoptosis by binding Bcl-2 and inhibiting its anti-apoptotic function (1). Upon apoptotic stimulation, Bak translocates from the cytosol to the mitochondrial membrane (2). Pro-apoptotic cascade activates BID, which oligomerizes Bak into pores that result in the release of cytochrome c (2, 3). In healthy cells, Bak associate with Bcl-xL and Mcl-1 but not with Bcl-2, Bcl-w or A1 and only when freed of both Bak will induce apoptosis.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 578
Alternate Names
  • Bcl2-L-7
  • BAK-LIKE
  • pro-apoptotic protein BAK
  • CDN1
  • BCL2-like 7 protein
  • Bcl-2-like protein 7
  • bcl2-L-7
  • Apoptosis regulator BAK
  • BCL2L7bcl-2 homologous antagonist/killer
  • BAKMGC3887
  • MGC117255
  • BCL2-antagonist/killer 1

Research Areas for BAK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

Bioinformatics Tool for BAK

Discover related pathways, diseases and genes to BAK. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related BAK Blog Posts

Check out the latest blog posts on BAK.
IRE1 alpha dependent apoptotic-signaling pathway
Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...    Read more.
p53 - Investigating an important tumor suppressor
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...    Read more.
Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis.
Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...    Read more.
Read more BAK related blogs.