Bag-1 Antibody (GP3.10G3E2) [Alexa Fluor® 594]

• Applications: WB, IP, KO
• Clone: GP3.10G3E2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Bag-1 Antibody (GP3.10G3E2) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human Bag-1
• Specificity: Detects the 36 kDa and 50 kDa isoforms of human Bag-1. Does not detect mouse Bag-1.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Bag-1 (Bcl-2-associated Athanogene 1) is a 31-kDa protein with an apparent molecular mass of 46 kDa that can bind to Bcl-2 and enhance its anti-apoptotic effect, resulting in increased protection from cell death induced by apoptotic stimuli. Bag-1 shares no significant homology with Bcl-2 or other Bcl-2 family proteins. The C-terminal region of Bag-1 binds the PDGF and HGF Receptor, and enhances growth factor-mediated protection from apoptosis. This represents a link between growth factor receptors and anti-apoptotic mechanisms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.