Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IP, mIF
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PB1/BAF180 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PB1/BAF180 has been proposed to function as a tumor suppressor protein. Recently, PB1/BAF180 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21. Alternate names for PB1/BAF180 include protein polybromo-1, polybromo-1D, BRG1-associated factor 180, hPB1, and PBRM1.
Bioinformatics
| Product By Gene ID |
55193 |
| Alternate Names |
- BAF180
- BAF180/PB1
- BAF180PB1BRG1-associated factor 180
- hPB1
- MGC156155
- MGC156156
- PB1
- PBRM1
- polybromo 1
- Polybromo-1D
- protein polybromo-1
|
Research Areas for BAF180/PB1
Find related products by research area and learn more about each of the different research areas below.
Chromatin Modifiers
