Bad Antibody [Alexa Fluor® 647]

• Reactivity: Hu, Mu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 647

Bad Antibody [Alexa Fluor® 647] Summary

• Immunogen: KLH-coupled human Bad synthetic peptide
  MFQIPEFEPSEQEDSSSAERGC
  Accession # Q92934
• Specificity: Detects human and mouse Bad in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Bad Antibody [Alexa Fluor® 647]

• Bad
• BBC2
• BBC6
• bcl2 antagonist of cell death
• BCL2-antagonist of cell death protein
• BCL2-associated agonist of cell death
• Bcl-2-binding component 6
• BCL2-binding component 6
• BCL2-binding protein
• BCL2L8
• Bcl2-L-8
• BCL2L8bcl2-L-8
• Bcl-2-like protein 8
• BCL-X/BCL-2 binding protein
• Bcl-XL/Bcl-2-associated death promoter

Background

Bcl-2 antagonist of cell death (BAD) is an 18 kDa cytoplasmic protein in the Bcl-2 family. It functions as a pro-apoptotic molecule by dimerizing with and inhibiting the anti-apoptotic proteins Bcl-2 and Bcl-xL. Prosurvival signals trigger the phosphorylation of BAD on Ser115, disrupting its interaction with Bcl-2 and Bcl-xL and resulting in protection from apoptosis. Over amino acid 1-21, human BAD shares 81 % aa sequence identity with mouse and rat BAD.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.