Bad Products

Antibodies
Bad Antibody
Bad Antibody
NB100-56080
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Bad Antibody (612312) [Unconj ...
Bad Antibody (612312) [Unconjugated]
MAB6405
Species: Hu
Applications: WB, IHC, ICC/IF, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Bad Antibody [Unconjugated]
Bad Antibody [Unconjugated]
AF819
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
ELISA Kits
Rat Bad ELISA Kit (Colorimetr ...
Rat Bad ELISA Kit (Colorimetric)
NBP2-69924
Species: Rt
Applications: ELISA
Human Bad ELISA Kit (Colorime ...
Human Bad ELISA Kit (Colorimetric)
NBP2-69922
Species: Hu
Applications: ELISA
Rat Bad ELISA Kit (Chemilumin ...
Rat Bad ELISA Kit (Chemiluminescence)
NBP2-69921
Species: Rt
Applications: ELISA
Lysates
Bad Knockout HeLa Cell Lysate ...
Bad Knockout HeLa Cell Lysate
NBP2-64717
Species: Hu
Applications: WB
Bad Overexpression Lysate
Bad Overexpression Lysate
NBL1-07900
Species: Hu
Applications: WB
Bad Overexpression Lysate
Bad Overexpression Lysate
NBP2-07881
Species: Hu
Applications: WB
Proteins
Recombinant Human Bad Protein ...
Recombinant Human Bad Protein
H00000572-P01
Species: Hu
Applications: WB, ELISA, PA, AP
Recombinant Human Bad Protein ...
Recombinant Human Bad Protein
H00000572-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
Bad Recombinant Protein Antig ...
Bad Recombinant Protein Antigen
NBP1-88698PEP
Species: Hu
Applications: AC

Description

Bad is a pro-apoptotic member of the Bcl-2 family. Bad will bind preferentially Bcl-xL over Bcl-2 through its partial (9-16 a.a) BH3 domain. Additionally, Bad can reverse the death repressor activity of Bcl-xL but not of Bcl-2. Upon dephosphorylation, activated Bad translocates to the mitochondria and displace Bcl-2 from tBid sequestration to initiate mitochondrial dysfunction. The switching on/off of its phosphorylation by growth/survival factors regulates Bad activity.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 572
Alternate Names
  • Bcl2-L-8
  • BCL-X/BCL-2 binding protein
  • BBC6
  • Bcl-XL/Bcl-2-associated death promoter
  • BCL2-binding protein
  • Bcl-2-like protein 8
  • BCL2-binding component 6
  • Bcl-2-binding component 6
  • BCL2-antagonist of cell death protein
  • BBC2
  • BCL2L8bcl2-L-8
  • bcl2 antagonist of cell death
  • BCL2-associated agonist of cell death

Research Areas for Bad

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
GPCR
Neuroscience
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for Bad

Discover related pathways, diseases and genes to Bad. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Bad Blog Posts

Check out the latest blog posts on Bad.
Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis?
Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death.  Novus Biologicals offers a variet...    Read more.
Altered expression of BCL2 in cancer
Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease.  For example, too little cell death can promote cell overgrowth a...    Read more.
Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...    Read more.
AKT Antibody Assays: A Complex Area with an Easy Solution
We at Novus Biologicals place a lot of emphasis on the kinase signaling pathways. Kinases, or phosphotransferase enzymes play a key role in phosphorylation signaling. Over 500 human protein kinases have so far been discovered. They play essential role...    Read more.
Read more Bad related blogs.