Bad [p Ser155] Antibody (27AT381)

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IP
Clone
27AT381
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.25 mg/ml

Order Details

Bad [p Ser155] Antibody (27AT381) Summary

Immunogen
This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to sequences in Ser155 region of mouse Bad and residue Ser155 is phosphorylated.
Modification
p Ser155
Specificity
mBad (27AT381) [Ser155]
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BAD
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

This antibody is reactive against Human, Mouse. In order to use this antibody with mouse samples, special protocol adjustments are required. Please contact technical support for assistance. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
0.25 mg/ml
Purity
Protein A or G purified

Alternate Names for Bad [p Ser155] Antibody (27AT381)

  • Bad
  • BBC2
  • BBC6
  • bcl2 antagonist of cell death
  • BCL2-antagonist of cell death protein
  • BCL2-associated agonist of cell death
  • Bcl-2-binding component 6
  • BCL2-binding component 6
  • BCL2-binding protein
  • BCL2L8
  • Bcl2-L-8
  • BCL2L8bcl2-L-8
  • Bcl-2-like protein 8
  • BCL-X/BCL-2 binding protein
  • Bcl-XL/Bcl-2-associated death promoter

Background

Apoptosis is a critical aspect of cellular function and is implicated in a broad range of human diseases, from cancer to neurodegenerative and cardiovascular diseases. Intrafamilial Bcl-2 protein contacts are thought to regulate key aspects of apoptosis. The corruption of apoptotic instructions is associated with a large subset of human diseases, ranging from cancer and cardiovascular disease to neurodegenerative diseases, and name just a few. Understanding regulation of apoptosis is necessary to constructing a strategy for pharmaceutical intervention. The BH3 domain of Bcl-2 family members has been identified as key to the Bcl-2 regulatory function, although details are not fully elucidated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Bad Antibody (NB100-94179) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Bad Antibody (NB100-94179)

Discover related pathways, diseases and genes to Bad Antibody (NB100-94179). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Bad Antibody (NB100-94179)

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Pathways for Bad Antibody (NB100-94179)

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Research Areas for Bad Antibody (NB100-94179)

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Blogs on Bad.

Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis?
Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death.  Novus Biologicals offers a variet...  Read full blog post.

Altered expression of BCL2 in cancer
Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease.  For example, too little cell death can promote cell overgrowth a...  Read full blog post.

Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...  Read full blog post.

AKT Antibody Assays: A Complex Area with an Easy Solution
We at Novus Biologicals place a lot of emphasis on the kinase signaling pathways. Kinases, or phosphotransferase enzymes play a key role in phosphorylation signaling. Over 500 human protein kinases have so far been discovered. They play essential role...  Read full blog post.

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Bioinformatics

Gene Symbol BAD
Entrez
Uniprot