Axl Antibody - Humanized, (Research Grade tilvestamab Biosimilar) - Low Endotoxin, Azide and BSA Free

The endocytosis ratio tilvestamab by U251 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 40% at antibody concentration of 1 nM.

Axl Antibody (tilvestamab) - Humanized P-AKT Test was evaluated using U251 cell. The max induction fold was approximately 1.43.

Immobilized human Axl FC at 2 ug/mL can bind Axl Antibody (tilvestamab) - Humanized, EC50=0.01542 ug/mL.

Human AXL HEK293 cells were stained with Axl Antibody (tilvestamab) - Humanized and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.07318 ug/mL.

Flow Cytometry: CHO Axl mAb (tilvestamab) - Humanized [NBP3-28445] - Axl expression on human monocyte-derived macrophages. The macrophages were treated with Tilvestamab PE antibody (blue), diluted 1:100, or human IgG1 PE isotype control antibody (red) for 30 minutes on ice. Image from a verified customer review. The customer used the PE-conjugated version of NBP3-28445, which is listed under NBP3-28445PE.

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Format: Low Endotoxin, Azide and BSA Free
• Concentration: LYOPH

Axl Antibody - Humanized, (Research Grade tilvestamab Biosimilar) - Low Endotoxin, Azide and BSA Free Summary

• Description: The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 146.16 kDa.
  
  Also known as 'tilvestamab'.
  
  This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: AXL / UFO
• Source: CHO
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: AXL
• Purity: Protein A purified
• Endotoxin Note: < 0.001EU/ug,determined by LAL method.

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for Array

• AI323647
• ARK
• AXL oncogene
• AXL receptor tyrosine kinase
• AXL transforming sequence/gene
• Axl
• EC 2.7.10
• EC 2.7.10.1
• JTK11
• Tyro7
• tyrosine-protein kinase receptor UFO
• UFO
• UFOoncogene AXL

Background

Axl is encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AXL
• Uniprot:
  • P30530(Human)