Axl [p Tyr779] Antibody (713610) [Phycoerythrin]

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HeLa human cervical epithelial carcinoma cell line either (A) untreated or (B) treated with 100 nM Pervanadate for 10 minutes was stained with Mouse Anti-Human Phospho-Axl (Y779) PE‑conjugated Monoclonal Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
713610
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

Axl [p Tyr779] Antibody (713610) [Phycoerythrin] Summary

Immunogen
Phosphopeptide containing the human Axl Y779 site
Modification
p Tyr779
Specificity
Detects human Phospho-Axl (Y779) in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
AXL
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Axl [p Tyr779] Antibody (713610) [Phycoerythrin]

  • AI323647
  • ARK
  • AXL oncogene
  • AXL receptor tyrosine kinase
  • AXL transforming sequence/gene
  • Axl
  • EC 2.7.10
  • EC 2.7.10.1
  • JTK11
  • Tyro7
  • tyrosine-protein kinase receptor UFO
  • UFO
  • UFOoncogene AXL

Background

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt), and Mer (human and mouse homologues of chicken c-Eyk) constitute a subfamily of the receptor tyrosine kinases (1, 2). The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. The human Axl cDNA encodes an 887 amino acid (aa) precursor that includes an 18 aa signal sequence, a 426 aa extracellular domain, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain. The extracellular domains of human and mouse Axl share 81% aa sequence identity. A short alternatively spliced form of human Axl is distinguished by a 9 aa deletion in the extracellular juxtamembrane region. These receptors bind the vitamin K-dependent protein growth arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor Protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis (3). This family of tyrosine kinase receptors is involved in hematopoiesis, embryonic development, tumorigenesis, and regulation of testicular functions. Phosphorylation of Tyrosine 779 provides a docking site for p85 subunits of PI 3-Kinase (4).

  1. Yanagita, M. (2004) Curr. Opin. Nephrol. Hypertens. 13:465.
  2. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  3. Holland, S. et al. (2005) Cancer Res. 65:9294.
  4. Weinger, J.G. et al. (2008) J. Neurochem. 106:134.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 IC6965U
Alexa Fluor 405 IC6965V
Alexa Fluor 488 IC6965G
Alexa Fluor 532 FAB6965X
Alexa Fluor 594 IC6965T
Alexa Fluor 647 IC6965R
Alexa Fluor 700 IC6965N
Alexa Fluor 750 IC6965S
Allophycocyanin IC6965A
Biotin FAB6965B
DyLight 350 FAB6965D
DyLight 405 FAB6965E
DyLight 488 FAB6965K
DyLight 550 FAB6965L
DyLight 594 FAB6965M
DyLight 650 FAB6965W
DyLight 680 FAB6965Y
DyLight 755 FAB6965Z
FITC FAB6965F
HRP FAB6965H
Janelia Fluor 549 FAB6965I
Janelia Fluor 646 FAB6965J
PerCP FAB6965C
Phycoerythrin IC6965P

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Bioinformatics

Gene Symbol AXL