Axin-2 Antibody (354214) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 354214
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Axin-2 Antibody (354214) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human Axin-2
  Tyr550-Gln760
  Accession # Q9Y2T1
• Specificity: Detects human Axin-2 in direct ELISAs. In this format, no cross-reactivity with recombinant human Axin-1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Axin-2 Antibody (354214) [Alexa Fluor® 405]

• AXIL
• axin 2
• Axin2
• Axin-2
• Axin-like protein
• Axis inhibition protein 2
• Conductin
• DKFZp781B0869
• MGC10366
• MGC126582

Background

Axin-2, also known as Conductin, is a 95 kDa cytoplasmic protein that inhibits Wnt signaling and promotes epithelial-mesenchymal transition. Axin 2 binds to beta -catenin, glycogen synthase kinase-3 (GSK-3 beta ), and the tumor suppressor APC. Loss of Axin-2 function is linked to carcinogenesis as well as abnormal bone and tooth development. Within aa 550-760, human Axin-2 shares 82% aa sequence identity with mouse and rat Axin-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.