Axin-2 Antibody (354214) [DyLight 350]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 354214
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 350

Axin-2 Antibody (354214) [DyLight 350] Summary

• Immunogen: E. coli-derived recombinant human Axin-2
  Tyr550-Gln760
  Accession # Q9Y2T1
• Specificity: Detects human Axin-2 in direct ELISAs. In this format, no cross-reactivity with recombinant human Axin-1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: AXIN2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Axin-2 Antibody (354214) [DyLight 350]

• AXIL
• axin 2
• Axin2
• Axin-2
• Axin-like protein
• Axis inhibition protein 2
• Conductin
• DKFZp781B0869
• MGC10366
• MGC126582

Background

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AXIN2