ATG7 Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC

ATG7 Antibody Blocking Peptide Summary

• Description: A Human ATG7 antibody blocking peptide
  
  Source: Synthetic (Accession #: O95352)
  
  Store vial at -20C prior to opening. Aliquot contents and freeze at -20C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4C as an undiluted liquid. Dilute only prior to immediate use.
• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: ATG7
• Purity: >95%

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This product should be used at 1.0 ug per 1.0 ul of antiserum in per assay.

Packaging, Storage & Formulations

• Storage: Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
• Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Preservative: No Preservative
• Purity: >95%

Alternate Names for ATG7 Antibody Blocking Peptide

• APG7 autophagy 7-like (S. cerevisiae)
• APG7
• APG7L
• APG7-LIKE
• ATG12-activating enzyme E1 ATG7
• ATG7 autophagy related 7 homolog (S. cerevisiae)
• ATG7
• Autophagy-related protein 7
• DKFZp434N0735
• GSA7
• hAGP7
• ubiquitin activating enzyme E1-like protein
• Ubiquitin-activating enzyme E1-like protein
• ubiquitin-like modifier-activating enzyme ATG7

Background

FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy. SUBUNIT: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. SUBCELLULAR LOCATION: Cytoplasm (Probable). ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12. SIMILARITY: Belongs to the ATG7 family.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ATG7
• Uniprot:
  • O95352()
  • O95352()
  • O95352()
  • O95352()