ASGPR1 Antibody (8D7) [FITC]

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Product Details

Summary
Product Discontinued
View other related ASGPR1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51109
    • Availability
      Product Discontinued

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ASGPR1 Antibody (8D7) [FITC] Summary

Immunogen
Crude rat liver membrane extracts
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ASGR1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
FITC
Format
FITC (A=495, E=519)
Buffer
PBS and 1.0% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 20 ug/ml
  • Flow Cytometry 1:10-1:1000
  • Immunoassay 20 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
In WB: Use under non-reducing conditions, detects 42 kDa band.

Alternate Names for ASGPR1 Antibody (8D7) [FITC]

  • ASGPR 1
  • ASGP-R 1
  • ASGPR
  • ASGPR1
  • ASGR1/ASGPR1
  • asialoglycoprotein receptor 1
  • CLEC4H1
  • CLEC4H1ASGPR1
  • C-type lectin domain family 4 member H1
  • Hepatic lectin H1
  • HL-1
  • MHL1
  • RHL1

Background

The asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor revealed its functional role in the binding, internalization and transport of a wide range of glycoproteins, which have exposed galactose or N-acetylgalactosamine residues, via the process of receptor-mediated endocytosis (RME). The ASGP receptor can bind a variety of important plasma proteins including transport proteins (i.e. transferrin), enzymes such as alkaline phosphatase, immunoglobulins including IgA, apoptotic hepatocytes, fibronectin and platelets. Additionally, the expression of the ASGP receptor has been clinically correlated to the level of hepatic function that is lost during liver diseases related to cancer, viral hepatitis, and cirrhosis. The ASGP receptor consists of major and minor subunits, which in the rat were identified as rat hepatic lectin (RHL) 1 and RHL 2/3, with molecular weights of respectively 42, 49 and 54 kDa. The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways. The monoclonal antibody 8D7 recognizes a subunit-specific epitope on RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for ASGPR1 Antibody (NBP1-51109). (Showing 1 - 1 of 1 FAQ).

  1. Is this sensitive and specific for hepatocyte or HCC cells?
    • NBP1-51109 is guaranteed for use on human and rat cells that express Asialoglycoprotein Receptor 1. This antibody will detect all cells expressing Asialoglycoprotein Receptor 1.

Secondary Antibodies

 

Isotype Controls

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Diseases for ASGPR1 Antibody (NBP1-51109)

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Blogs on ASGPR1

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol ASGR1
Entrez
Uniprot

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