ARHGEF4 Antibody (ARHGEF-08) [HRP]

• Reactivity: Hu
• Applications: WB, Flow
• Clone: ARHGEF-08
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: HRP

ARHGEF4 Antibody (ARHGEF-08) [HRP] Summary

• Immunogen: Recombinant fragment of human ARHGEF4 (amino acids 143-271)
• Specificity: The antibody MEM-174 recognizes CD11b antigen (Mac-1 alpha), a 165-170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ARHGEF4
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow (Intracellular)
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Alternate Names for ARHGEF4 Antibody (ARHGEF-08) [HRP]

• APC-stimulated guanine nucleotide exchange factor 1
• Asef
• ASEF1
• ASEFAPC-stimulated guanine nucleotide exchange factor
• GEF4
• KIAA1112
• Rho guanine nucleotide exchange factor (GEF) 4
• rho guanine nucleotide exchange factor 4
• STM6

Background

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through Gucleotide exchange protein coupled receptors. Acts as guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. This protein is similar to rat collybistin protein. Alternative splicing of the gene generates two transcript variants which encode different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ARHGEF4