Species: Hu
Applications: WB, ELISA
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, Flow
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through Gucleotide exchange protein coupled receptors. Acts as guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. This protein is similar to rat collybistin protein. Alternative splicing of the gene generates two transcript variants which encode different isoforms.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
50649 |
| Alternate Names |
- APC-stimulated guanine nucleotide exchange factor 1
- Asef
- Asef1
- ASEF1
- ASEFAPC-stimulated guanine nucleotide exchange factor
- GEF4
- KIAA1112
- Rho guanine nucleotide exchange factor (GEF) 4
- rho guanine nucleotide exchange factor 4
- STM6
|
Research Areas for ARHGEF4
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction
