ARHGEF4 Products

Description

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through Gucleotide exchange protein coupled receptors. Acts as guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. This protein is similar to rat collybistin protein. Alternative splicing of the gene generates two transcript variants which encode different isoforms.

Bioinformatics

Entrez	50649 Human
Uniprot	NP_056135 Human NM_015320 Human Q9NR80 Human
Product By Gene ID	50649
Alternate Names	APC-stimulated guanine nucleotide exchange factor 1 GEF4 Asef1 ASEF1 Asef KIAA1112 rho guanine nucleotide exchange factor 4 STM6 ASEFAPC-stimulated guanine nucleotide exchange factor Rho guanine nucleotide exchange factor (GEF) 4

Diseases related to ARHGEF4

Discover more about diseases related to ARHGEF4.

Epilepsy
Autistic Disorder
Malignant Neoplasms
Developmental Delay (disorder)
Attention Deficit Hyperactivity Disorder
Teratocarcinoma

Research Areas for ARHGEF4

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Signal Transduction

Bioinformatics Tool for ARHGEF4

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