ApoE4 Antibody (4E4)


Western Blot: ApoE4 Antibody (4E4) [NBP1-49529] - Analysis of ApoE4 expression in concentrated supernatants of CHO cells secreting human ApoE2, ApoE3 or ApoE4 using NBP1-49529. Image courtesy of Dr. Marko Roblek from ...read more
Immunocytochemistry/ Immunofluorescence: ApoE4 Antibody (4E4) [NBP1-49529] - HepG2 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were ...read more

Product Details

Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IP
1 mg/ml

ApoE4 Antibody (4E4) Summary

Synthetic peptide made to an internal region of human ApoE4 (within residues 100-150) [UniProt# P02649]
This antibody is specific for ApoE4. It does not cross-react with the ApoE2 or ApoE3 isoforms.
IgG1 Kappa
Protein G purified
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  • Western Blot 1:1000-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 2-5 ug/ml
  • Immunoprecipitation 1:10-1:500
Application Notes
This ApoE4 antibody (4E4) is useful for ELISA, Immunoprecipitation, and Western blot where a band can been seen at approximately 34 kDa. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
34 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
ApoE4 Lysate (NBP2-65839)

Reactivity Notes


Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
1 mg/ml
Protein G purified

Alternate Names for ApoE4 Antibody (4E4)

  • Apo-E
  • apolipoprotein E
  • apolipoprotein E3
  • late onset)
  • MGC1571


Apolipoprotein E has three isoforms namely ApoE2, ApoE3, and ApoE4 that differ from each other by single amino acid interchanges at residues 130/176, and ApoE4 is an isoforms which contains arginine at 130 and 176 locations. ApoE4 is mainly synthesized in liver and brain, and is widely expressed in other tissues also. ApoE4 functions have been linked to neuronal plasticity, synaptogenesis etc. and ApoE4 expressing subjects have reduced capacity for synaptic plasticity, increased amyloid-beta deposition, and early onset of Alzheimer's disease (AD). ApoE4 is also linked to progression/poor clinical outcomes in TBI (traumatic brain injury), multiple sclerosis, stroke, frontotemporal dementia, and Parkinson's disease. The neuropathological effects of apoE4 includes impaired neurite outgrowth, cytoskeletal disruption/hyperphosphorylation of tau, neuronal mitochondrial dysfunction, impaired synaptogenesis, increased amyloid beta production as well as clearance/deposition, increased lysosomal leakage and neuronal apoptosis, cerebral neuropathology and impaired learning and memory.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for ApoE4 Antibody (NBP1-49529). (Showing 1 - 1 of 1 FAQ).

  1. I'm interested in your product ApoE4 Ab (NBP1-49529). According to your web information, it is specific to ApoE4 only, no cross interaction with E2 and E3. Is that right? Would you please let me know if your have any references for this? Has anyone tried in their experiments? How was it?
    • Unfortunately I do not have any references on file regarding this antibody that I can pass along at this time. The lab has indicated that it will not cross react and therefore we will stand by that claim with our 100% guarantee. That way if you do see any cross reaction we would be happy to send you a replacement or refund. The western blot image on the datasheet should also help answer your question.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-49529AF405
Alexa Fluor 488 Labeled NBP1-49529AF488
Alexa Fluor 647 Labeled NBP1-49529AF647
Alexa Fluor 700 Labeled NBP1-49529AF700
Biotin Labeled NBP1-49529B
DyLight 405 Labeled NBP1-49529V
DyLight 488 Labeled NBP1-49529G
DyLight 550 Labeled NBP1-49529R
DyLight 650 Labeled NBP1-49529C
FITC Labeled NBP1-49529F
HRP Labeled NBP1-49529H

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Blogs on ApoE4.

The C99 fragment of amyloid precursor protein (APP)
Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...  Read full blog post.

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Gene Symbol APOE