ApoE4 Antibody (4E4) [FITC]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Clone
4E4
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

ApoE4 Antibody (4E4) [FITC] Summary

Immunogen
Synthetic peptide made to an internal region of human ApoE4 (within residues 100-150) [UniProt# P02649]
Localization
Secreted
Specificity
This antibody is specific for ApoE4. It does not cross-react with the ApoE2 or ApoE3 isoforms.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
APOE
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
This ApoE4 antibody (4E4) is useful for ELISA, Immunoprecipitation, and Western blot where a band can been seen at approximately 34 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
34 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ApoE4 Antibody (4E4) [FITC]

  • Apo-E
  • apolipoprotein E
  • apolipoprotein E3
  • late onset)
  • MGC1571

Background

Apolipoprotein E has three isoforms namely ApoE2, ApoE3, and ApoE4 that differ from each other by single amino acid interchanges at residues 130/176, and ApoE4 is an isoforms which contains arginine at 130 and 176 locations. ApoE4 is mainly synthesized in liver and brain, and is widely expressed in other tissues also. ApoE4 functions have been linked to neuronal plasticity, synaptogenesis etc. and ApoE4 expressing subjects have reduced capacity for synaptic plasticity, increased amyloid-beta deposition, and early onset of Alzheimer's disease (AD). ApoE4 is also linked to progression/poor clinical outcomes in TBI (traumatic brain injury), multiple sclerosis, stroke, frontotemporal dementia, and Parkinson's disease. The neuropathological effects of apoE4 includes impaired neurite outgrowth, cytoskeletal disruption/hyperphosphorylation of tau, neuronal mitochondrial dysfunction, impaired synaptogenesis, increased amyloid beta production as well as clearance/deposition, increased lysosomal leakage and neuronal apoptosis, cerebral neuropathology and impaired learning and memory.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-49529B
DyLight 405 Labeled NBP1-49529V
DyLight 488 Labeled NBP1-49529G
DyLight 550 Labeled NBP1-49529R
DyLight 650 Labeled NBP1-49529C
HRP Labeled NBP1-49529H

Additional ApoE4 Products

ApoE4 NBP1-49529F

Bioinformatics Tool for ApoE4 Antibody (NBP1-49529F)

Discover related pathways, diseases and genes to ApoE4 Antibody (NBP1-49529F). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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PTMs for ApoE4 Antibody (NBP1-49529F)

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Blogs on ApoE4.

The C99 fragment of amyloid precursor protein (APP)
Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...  Read full blog post.

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Bioinformatics

Gene Symbol APOE