ApoE4 Products


Apolipoprotein E (APOE) is an apolipoprotein located in chylomicrons and intermediate-density lipoproteins that is necessary for the normal catabolism of triglyceride-rich lipoprotein constituents in the liver. APOE has recently been shown to be involseveral biological processes other than lipoprotein transport, including cognition and immunoregulation.

Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of very low-density lipoproteins (VLDL), which remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes.

There are three known Apo E isoforms (ApoE2, E3 and E4), which are strongly associated with cardiovascular disease and/orAlzheimer's disease. Therefore, ApoE antibodies have become useful tools for research in both of these areas.


Entrez Human
Uniprot Human
Product By Gene ID 348
Alternate Names
  • Apo-E
  • MGC1571
  • apolipoprotein E3
  • late onset)
  • apolipoprotein E

Research Areas for ApoE4

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Lipid and Metabolism
Neuronal Cell Markers
Signal Transduction

Bioinformatics Tool for ApoE4

Discover related pathways, diseases and genes to ApoE4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related ApoE4 Blog Posts

Check out the latest blog posts on ApoE4.
The C99 fragment of amyloid precursor protein (APP)
Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...    Read more.
Read more ApoE4 related blogs.