ApoE4 Products

Description

Apolipoprotein E (APOE) is an apolipoprotein located in chylomicrons and intermediate-density lipoproteins that is necessary for the normal catabolism of triglyceride-rich lipoprotein constituents in the liver. APOE has recently been shown to be involseveral biological processes other than lipoprotein transport, including cognition and immunoregulation.

Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of very low-density lipoproteins (VLDL), which remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes.

There are three known Apo E isoforms (ApoE2, E3 and E4), which are strongly associated with cardiovascular disease and/orAlzheimer's disease. Therefore, ApoE antibodies have become useful tools for research in both of these areas.

Bioinformatics

Entrez	348 Human
Uniprot	P02649 Human P02649 Human
Product By Gene ID	348
Alternate Names	Apo-E apolipoprotein E apolipoprotein E3 late onset) MGC1571

Research Areas for ApoE4

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Apoptosis
Lipid and Metabolism
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Signal Transduction

Related ApoE4 Blog Posts

Check out the latest blog posts on ApoE4.

The C99 fragment of amyloid precursor protein (APP) Alzheimer’s Disease (AD) is a neurodegenerative disorder that is characterized by an abundance of the beta-amyloid peptide in the brain.  When AD was first discovered, it was determined that beta-amyloid was produced as a result of the prote...    Read more.

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