Apc7 Antibody

Images

 
Western Blot: Apc7 Antibody [NBP1-77379] - Analysis in HeLa cell lysate with antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: Apc7 Antibody [NBP1-77379] - Rat kidney tissue with APC7 antibody at 20 ug/mL.
Western Blot: Apc7 Antibody [NBP1-77379] - Analysis of APC7 in rat kidney tissue lysate with APC7 antibody at (A) 1 and (B) 2 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Apc7 Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human APC7. The immunogen is located within amino acids 520 - 570 of APC7.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ANAPC7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Theoretical MW
68 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
Apc7 Peptide (NBP1-77379PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Apc7 Antibody

  • anaphase promoting complex subunit 7
  • anaphase-promoting complex subunit 7
  • APC7Cyclosome subunit 7

Background

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ANAPC7
Uniprot