Alpha Actinin 4 Antibody Pair

Product Discontinued

Alpha Actinin 4 Antibody Pair Summary

• Description: Quality control test: Standard curve using recombinant protein (H00000081-Q01) as an analyte. This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACTN4.
  
  
• Capture antibody: mouse monoclonal anti-ACTN4 IgG2a (100 ug)
• Detection antibody: biotinylated mouse monoclonal anti-ACTN4 IgG2a Kappa (50 ug)
• Standard Curve Range: 1 ng/ml to 100 ng/ml
• Assay Type: Sandwich ELISA
• Clonality: Monoclonal
• Gene: ACTN4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Sandwich ELISA 0.1 ng/ml - 100 ng/ml

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Alpha Actinin 4 Antibody Pair

• actinin alpha4 isoform
• actinin, alpha 4
• ACTININ-4
• alpha-actinin-4
• DKFZp686K23158
• F-actin cross-linking protein
• focal segmental glomerulosclerosis 1
• FSGS
• FSGS1
• Non-muscle alpha-actinin 4

Background

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: ACTN4