Alpha Actinin 4 Products

Description

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Bioinformatics

Entrez	60595 Mouse 81 Human
Uniprot	NM_004924 Human NP_004915 Human NP_004915.2 Human O43707 Human
Product By Gene ID	81
Alternate Names	actinin alpha4 isoform actinin, alpha 4 ACTININ-4 alpha-actinin-4 DKFZp686K23158 F-actin cross-linking protein focal segmental glomerulosclerosis 1 FSGS FSGS1 Non-muscle alpha-actinin 4

Research Areas for Alpha Actinin 4

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Phospho-Specific