Alpha Actinin 4 Antibody (93) [DyLight 650]

• Reactivity: Hu
• Applications: IHC
• Clone: 93
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

Alpha Actinin 4 Antibody (93) [DyLight 650] Summary

• Immunogen: Recombinant full-length human Alpha Actinin 4 protein (Uniprot: O43707)
• Localization: Nucleus, Cytoplasm
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACTN4
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Alpha Actinin 4 Antibody (93) [DyLight 650]

• actinin alpha4 isoform
• actinin, alpha 4
• ACTININ-4
• alpha-actinin-4
• DKFZp686K23158
• F-actin cross-linking protein
• focal segmental glomerulosclerosis 1
• FSGS
• FSGS1
• Non-muscle alpha-actinin 4

Background

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACTN4