Aldehyde Dehydrogenase 1‑A1/ALDH1A1 was detected in immersion fixed A549 human lung carcinoma cell line using Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody (Catalog # MAB5869) at 10 µg/mL ...read more
Aldehyde Dehydrogenase 1‑A1/ALDH1A1 was detected in immersion fixed paraffin-embedded sections of human brain (substantia nigra) using Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody ...read more
Simple Western lane view shows lysates of human liver tissue, loaded at 0.2 mg/mL. A specific band was detected for Aldehyde Dehydrogenase 1‑A1/ALDH1A1 at approximately 58 kDa (as indicated) using 20 µg/mL of Mouse ...read more
Western blot shows lysates of human liver tissue, mouse liver tissue, and rat lung tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody (Catalog # ...read more
E. coli-derived recombinant human Aldehyde Dehydrogenase 1-A1/ALDH1-A1 Ser2-Ser501 Accession # P00352
Detects human Aldehyde Dehydrogenase 1-A1/ALDH1-A1 in direct ELISAs and Western blots. In direct ELISAs, approximatly 50% cross‑reactivity with recombinant human Aldehyde Dehydrogenase 1-A2 is observed.
Protein A or G purified from hybridoma culture supernatant
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Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Sterile PBS to a final concentration of 0.5 mg/mL.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Aldehyde Dehydrogenase 1-A1/ALDH1A1 Antibody (703410) [Unconjugated]
acetaldehyde dehydrogenase 1
aldehyde dehydrogenase 1 family, member A1
aldehyde dehydrogenase 1, soluble
Aldehyde Dehydrogenase 1A1
Aldehyde Dehydrogenase 1-A1
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
aldehyde dehydrogenase, liver cytosolic
ALDH class 1
retinal dehydrogenase 1
retinaldehyde dehydrogenase 1
Aldehyde dehydrogenases (ALDHs) are NAD(P)+-dependent enzymes that detoxify aldehydes by oxidizing them to carboxylic acids. Nineteen ALDHs are present in humans, expressed in a variety of organelles and having different substrate preferences (1). ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid (2). ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea (3). ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development (4). The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells (5). ALDH1A1 is a major enzyme in the oxidation of acetaldehyde, a toxic metabolite of ethanol (6).
Marchitti, S.A.et al. (2008) Expert Opin. Drug Metab. Toxicol. 4:697.
Zhao, D. et al. (1996) Eur. J. Biochem. 240:15.
King, G. and Holmes, R. (1997) Adv. Exp. Med. Biol. 414:19.
Jacobs, F.M. et al. (2007) Development 134:2673.
Chute, J.P. et al. (2006) Proc. Natl. Acad. Sci. USA. 103:11707.
Ueshima, Y. et al. (1993) Alcohol Alcohol. 1B:15.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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