Akirin2 Antibody - BSA Free

Western Blot: Akirin2 Antibody [NBP1-76347] - Human Brain tissue lysate with Akirin2 antibody at 0.5 ug/ml in (A) the absence and (B) the presence ofblocking peptide.

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Akirin2 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Akirin2 Antibody - BSA Free (NBP1-76347) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2. The immunogen is located within amino acids 80 - 130 of Akirin2. Amino Acid Squence: ETSFQQTDPCCTSDA
• Predicted Species: Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AKIRIN2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 0.5 ug/ml
• Control Peptide:

  Akirin2 Peptide (NBP1-76347PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for Akirin2 Antibody - BSA Free

• akirin 2
• akirin-2
• C6orf166
• chromosome 6 open reading frame 166
• dJ486L4.2
• FBI1
• FLJ10342
• fourteen-three-three beta interactant 1

Background

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AKIRIN2
• Uniprot:
  • EAW48578(Human)