AHR Antibody

Product Discontinued

AHR Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from C-terminus of human Aryl Hydrocarbon Receptor.
• Epitope: C-terminal region of human.
• Specificity: Human Aryl Hydrocarbon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TCHHL1 (56%).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AHR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 15 - 20 ug/ml
• Control:

  AHR Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (94%), Monkey (88%), Bat (88%), Guinea pig (88%), Marmoset (81%), Bovine (81%), Hamster (81%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for AHR Antibody

• Ah receptor
• AHR
• AH-receptor
• aryl hydrocarbon receptor
• BHLHE76
• bHLHe76aromatic hydrocarbon receptor
• Class E basic helix-loop-helix protein 76

Background

The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for AHR Antibody (NB110-39035) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Other.

reviewed by: Verified Customer ELISA Other 06/04/2009

Summary

• Application: ELISA
• Sample Tested: Guinea Pig Liver Extract
• Species: Other
• Lot: 7945/7946AP3-1

Bioinformatics

• Gene Symbol: AHR
• Entrez:
  • 196(Human)