AGTR-2 Antibody (364805)

• Reactivity: Hu
• Applications: Flow, CyTOF-ready
• Clone: 364805
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

AGTR-2 Antibody (364805) Summary

• Immunogen: HEK293 human embryonic kidney cell line transfected with human AGTR-2
  Met1-Ser363
  Accession # P50052
• Specificity: Detects human AGTR‑2. Stains human AGTR-2-transfected cells but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: AGTR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for AGTR-2 Antibody (364805)

• AGTR2
• AGTR-2
• Angiostensin Receptor
• angiotensin II receptor, type 2
• Angiotensin II type-2 receptor
• angiotensin receptor 2
• AT2
• AT2ATGR2
• AT2R
• MRX88
• MRX88type-2 angiotensin II receptor

Background

AGTR-2, also known as AT2, is a 7-transmembrane protein that belongs to family 1 of G protein-coupled receptors. Both AGTR-2 and AGTR‑1 bind Angiotensin II and function in the control of hemodynamics. In contrast to AGTR‑1, which promotes vasoconstriction and cell proliferation, AGTR-2 inhibits growth and promotes apoptosis. In addition, Angiotensin II-induced AGTR-2 signaling induces the release of nitric oxide in the heart, kidney, and brain and participates in tissue morphogenesis and repair. Human AGTR-2 shares 92% amino acid sequence identity with mouse and rat AGTR-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for AGTR-2 Antibody (MAB3659)(1)

Publication using MAB3659

• P Namsolleck, L de Vries, GN Moll LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice Peptides, 2022-12-06;160(0):170920. 2022-12-06 [PMID: 36493954] (IHC, Human)

Bioinformatics

• Gene Symbol: AGTR2
• Uniprot:
  • P50052()