AGPAT6 Antibody [DyLight 488]

Product Discontinued

AGPAT6 Antibody [DyLight 488] Summary

• Immunogen: A synthetic peptide made to an N-terminal portion of human AGPAT6 (between residues 1-100). [Swiss-Prot Q86UL3]
• Localization: Membrane
• Predicted Species: Rat (100%), Porcine (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AGPAT6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This AGPAT6 antibody is useful for Western blot, where a band is seen at ~58 kDa representing AGPAT6 protein.
  
  The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, monkey and mouse. Predicted to react with bovine, porcine, and rat based on 100% sequence homology.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for AGPAT6 Antibody [DyLight 488]

• 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acidacyltransferase, zeta)
• Acyl-CoA:glycerol-3-phosphate acyltransferase 4
• DKFZp586M1819,1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
• EC 2.3.1.15
• glycerol-3-phosphate acyltransferase 4,1-AGP acyltransferase 6
• glycerol-3-phosphate acyltransferase 6,1-AGPAT 6
• GPAT4,1-acylglycerol-3-phosphate O-acyltransferase 6
• LPAAT-zetaLPAATZ
• Lysophosphatidic acid acyltransferase zeta
• testis spermatogenesis apoptosis-related protein 7
• TSARG7

Background

AGPAT6 is a novel glycerolipid acyltransferase of the ER, which is crucial for the production of milk fat by the mammary gland. Agpat6 deficient mice exhibit a 25% reduction in body weight and resistance to both diet-induced and genetically induced obesity. The reduced body weight is associated with increased energy expenditure, reduced triglyceride accumulation in BAT and WAT, reduced white adipocyte size, and lack of adipose tissue in the subdermal region. AGPAT6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family. (1)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AGPAT6