AGPAT6 Antibody [Alexa Fluor® 405]

Product Discontinued

AGPAT6 Antibody [Alexa Fluor® 405] Summary

• Immunogen: A synthetic peptide made to an N-terminal portion of human AGPAT6 (between residues 1-100). [Swiss-Prot Q86UL3]
• Localization: Membrane
• Predicted Species: Rat (100%), Porcine (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AGPAT6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This AGPAT6 antibody is useful for Western blot, where a band is seen at ~58 kDa representing AGPAT6 protein.
  
  The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, monkey and mouse. Predicted to react with bovine, porcine, and rat based on 100% sequence homology.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for AGPAT6 Antibody [Alexa Fluor® 405]

• 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acidacyltransferase, zeta)
• Acyl-CoA:glycerol-3-phosphate acyltransferase 4
• DKFZp586M1819,1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
• EC 2.3.1.15
• glycerol-3-phosphate acyltransferase 4,1-AGP acyltransferase 6
• glycerol-3-phosphate acyltransferase 6,1-AGPAT 6
• GPAT4,1-acylglycerol-3-phosphate O-acyltransferase 6
• LPAAT-zetaLPAATZ
• Lysophosphatidic acid acyltransferase zeta
• testis spermatogenesis apoptosis-related protein 7
• TSARG7

Background

Glycerol-3-phosphate acyltransferase 4 (GPAT4), also known as AGPAT6, is a novel glycerolipid acyltransferase of the ER, which is crucial for the production of milk fat by the mammary gland.

Agpat6 deficiency leads to a reduction in body weight and resistance to both diet-induced and genetically induced obesity. This reduced body weight is associated with increased energy expenditure, reduced triglyceride accumulation in BAT and WAT, reduced white adipocyte size, and lack of adipose tissue in the subdermal region. AGPAT6 fills a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AGPAT6