ADAMTS5 Antibody


There are currently no images for ADAMTS5 Antibody (NB100-74343).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity Hu, Po, BvSpecies Glossary
Applications WB
1.0 mg/ml

Order Details

ADAMTS5 Antibody Summary

Synthetic peptide corresponding to residues C K(a.a. 636) N G Y Q S D A K G V K T F(a.a. 649) of human ADAMTS5.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
PBS containing 1 mg/ml BSA
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


  • Western Blot 1 ug/ml
Application Notes
By Western blot, this antibody detects a major band at ~68 kDa protein representing ADAMTS5 from porcine cartilage extract. On human recombinant ADAMTS5 this antibody detects a major band at ~85 kDa. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

Reactivity Notes

Porcine, Bovine and Human.

Alternate Names for ADAMTS5 Antibody

  • A disintegrin and metalloproteinase with thrombospondin motifs 11
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5
  • ADAM-TS 11
  • ADAM-TS 5
  • ADAMTS11
  • ADAMTS-11
  • ADAM-TS5
  • ADAMTS-5
  • ADMP2
  • ADMP-2
  • ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5
  • Aggrecanase 2
  • Aggrecanase-2
  • disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738
  • EC 3.4.24
  • EC 3.4.24.-
  • EC
  • EC


ADAMTS5, also known as Implantin or Aggrecanase 2, is a member of the larger family of ADAM (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin-5 motif) was first described as ADAMTS5, a protein elevated in mice during the peri-implantion period. At the same time, another group identified Aggrecanase 11, a protein elevated in arthritic synovium. The name was later changed to ADAMTS5. ADAMTS5 is expressed in human and mouse. It has been found in heart, lung, cervix, uterus, ovary, brain, cartilage, and numerous other tissues, as well as chondroblastoma cell lines. Initial observations indicated a role for ADAMTS5 in aggrecan cleavage and cartilage destruction, especially in arthritis, and potentially a role in embryo implantation. ADAMTS5 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to efficiently cleave Aggrecan. In addition to the metalloprotease domain, ADAMTS5 has a propeptide domain, a prohormone convertase (PC, furin) cleavage site, a cysteine-rich domain, a spacer domain, and two thrombospondin-1 like domains. ADAMTS5 is inhibited by the endogenous MMP inhibitors (TIMP1, 2, 3, and 4) but most efficiently by TIMP3. Unlike many of the ADAMs proteases, ADAMTS5 does not have a transmembrane domain, and is a secreted protein. Full length ADAMTS5 is a 930 amino acid protein with a predicted molecular mass is 101.7 kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS5 a greater apparent molecular weight on reduced SDS PAGE gels. When ADAMTS5 is secreted, it is cleaved at the furin cleavage site (predicted molecular mass 73.2 kDa) and then further cleaved to generate a range of smaller forms.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, IP
Species: Hu, Rt
Applications: WB, ELISA, S-ELISA
Species: Hu, Mu
Applications: WB, IHC, IP
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: WB, IHC, ICC
Species: Hu, Rt, Bv, Rb
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P

Publications for ADAMTS5 Antibody (NB100-74343) (0)

There are no publications for ADAMTS5 Antibody (NB100-74343).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for ADAMTS5 Antibody (NB100-74343) (0)

There are no reviews for ADAMTS5 Antibody (NB100-74343). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for ADAMTS5 Antibody (NB100-74343) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Additional ADAMTS5 Antibody Products

Related Products by Gene

Bioinformatics Tool for ADAMTS5 Antibody (NB100-74343)

Discover related pathways, diseases and genes to ADAMTS5 Antibody (NB100-74343). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for ADAMTS5 Antibody (NB100-74343)

Discover more about diseases related to ADAMTS5 Antibody (NB100-74343).

Pathways for ADAMTS5 Antibody (NB100-74343)

View related products by pathway.

PTMs for ADAMTS5 Antibody (NB100-74343)

Learn more about PTMs related to ADAMTS5 Antibody (NB100-74343).

Research Areas for ADAMTS5 Antibody (NB100-74343)

Find related products by research area.

Blogs on ADAMTS5

There are no specific blogs for ADAMTS5, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol ADAMTS5

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB100-74343 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought