ADAMTS5 Products

Description

ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.

Bioinformatics

Entrez	11096 Human
Uniprot	NM_007038 Human Q9UNA0 Human
Product By Gene ID	11096
Alternate Names	A disintegrin and metalloproteinase with thrombospondin motifs 11 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 5 (aggrecanase-2) ADAM metallopeptidase with thrombospondin type 1 motif, 5 ADAM-TS 11 ADAM-TS 5 ADAMTS-11 ADAM-TS5 ADAMTS-5 ADMP2 ADMP-2A disintegrin and metalloproteinase with thrombospondin motifs 5 aggrecanase-2 Aggrecanase-2 disintegrin-like and metalloprotease with thrombospondin type 1 motif, 510ADAMTS11FLJ36738 EC 3.4.24 EC 3.4.24.- EC 3.4.24.14 EC 3.4.24.82

Research Areas for ADAMTS5

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GPCR