Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Images

 
Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - Mouse tissue extract (50 ug) was separated by 10% SDS-PAGE, and the membrane was blotted with Activin A Receptor type I antibody diluted at ...read more
Immunohistochemistry-Frozen: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - Frozen sectioned adult mouse retina. Green: Activin A Receptor type I protein stained by Activin A Receptor type I antibody ...read more
Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - A. 50 ug rat liver lysate/extract 7.5 % SDS-PAGE Activin A Receptor type I antibody dilution: 1:1000
Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - Human pancreatic cancer cell lines. Image provided by verified customer review.

Product Details

Summary
Reactivity Mu, Rt, Hu, Bv, Mk, XpSpecies Glossary
Applications WB, IHC, IHC-Fr
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.9 mg/ml

Order Details

Activin RIA/ALK-2/Activin Receptor Type 1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Activin A Receptor type I. The exact sequence is proprietary.
Localization
Membrane
Predicted Species
Human (100%), Xenopus (93%), Monkey (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ACVR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Frozen 1:100-1:1000
Theoretical MW
57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reviewed Applications
Read 1 Review rated 5
using
NBP1-33500 in the following applications:

Reactivity Notes

Expected cross reactivity based on sequence homology: Rhesus Monkey (100%), Xenopus laevis (93%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.9 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

  • activin A receptor, type I
  • Activin RIA
  • ActivinRIA
  • ACTRI
  • ACVR1
  • ACVR1A
  • ACVRLK2
  • ALK2
  • ALK-2
  • FOP
  • SKR1
  • TSRI

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500) (0)

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Review for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: WB.

Reviews using NBP1-33500:
Filter by Applications
WB
(1)
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(1)
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Images Ratings Applications Species Date Details
Western Blot Activin RIA/ALK-2/Activin Receptor Type 1 NBP1-33500
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reviewed by:
Prabir Chakraborty
WB Human 02/10/2014
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Summary

ApplicationWestern Blot
Sample TestedHUMAN PANCREATIC CANCER CELLINES
SpeciesHuman
Lot40142
CommentsDETECTS A SPECIFIC BAND AROUND 75KDa AND THE ANTIBODY MAY BE DILUTED TO LOWER CONCENTRATIONS OF 1:5000.
SHOWS FEW MORE BANDS BETWEEN 50KDa AND 75KDa AT HIGHER EXPOSURES.

Blocking

Blocking Details4% BSA IN TBST, 1H AT RT

Primary Anitbody

Dilution Ratio1:2000 IN 1% BSA IN TBST AT 4*C O/N

Secondary Antibody

Secondary DescriptionGoat anti-rabbit IgG-HRP
Secondary Manufacturer Cat#sc-2301
Secondary Concentration1:10,000IN TBST FOR 1H AT RT

Details

Detection NotesECL

Comments

CommentsDETECTS A SPECIFIC BAND AROUND 75KDa AND THE ANTIBODY MAY BE DILUTED TO LOWER CONCENTRATIONS OF 1:5000.
SHOWS FEW MORE BANDS BETWEEN 50KDa AND 75KDa AT HIGHER EXPOSURES.

Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500)

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Recent Reviews

5
5
1
4
0
3
0
2
0
1
0

Prabir Chakraborty
02/10/2014
Application: WB
Species: Human

Bioinformatics

Gene Symbol ACVR1
Entrez