Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - Mouse tissue extract (50 ug) was separated by 10% SDS-PAGE, and the membrane was blotted with Activin A Receptor type I antibody diluted at 1:500.

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - A. 50 ug rat liver lysate/extract 7.5 % SDS-PAGE Activin A Receptor type I antibody dilution: 1:1000

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33500] - Human pancreatic cancer cell lines. Image provided by verified customer review.

Activin A Receptor type I antibody detects Activin A Receptor type I protein by immunohistochemical analysis.Sample: Frozen sectioned adult mouse retina. Green: Activin A Receptor type I protein stained by Activin A Receptor type I antibody (NBP1-33500) diluted at 1:250.Red: Protein kinase C alpha staining.Blue: Fluoroshield with DAPI . br>Antigen Retrieval: Trilogy(TM) (EDTA based, pH 8.0) buffer, 15min

• Reactivity: Mu, Rt, Hu, Bv, RM, Xp
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Activin RIA/ALK-2/Activin Receptor Type 1 Antibody Summary

• Description: Novus Biologicals Rabbit Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Activin RIA/ALK-2/Activin Receptor Type 1. The exact sequence is proprietary.
• Localization: Membrane
• Predicted Species: Human (100%), Xenopus (93%), Bovine (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ACVR1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Frozen 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 57 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (93%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS, 1% BSA, 20% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Antigen Affinity-purified

Alternate Names for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

• activin A receptor, type I
• Activin RIA
• ActivinRIA
• ACTRI
• ACVR1
• ACVR1A
• ACVRLK2
• ALK2
• ALK-2
• FOP
• SKR1
• TSRI

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Review for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Prabir Chakraborty WB Human 02/10/2014

Summary

• Application: Western Blot
• Sample Tested: HUMAN PANCREATIC CANCER CELLINES
• Species: Human
• Lot: 40142

Bioinformatics

• Gene Symbol: ACVR1