BMPR-II Antibody

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PC‑3 human prostate cancer cell line was stained with Goat Anti-Human BMPR‑II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF811, filled histogram) or control antibody (Catalog # AB-108-C, open ...read more
BMPR-II was detected in formalin fixed paraffin-embedded sections of human prostate using Goat Anti-Human BMPR-II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF811) at 15 µg/mL overnight at 4 °C. Tissue ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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BMPR-II Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMPR-II
Ala26-Ile151
Accession # Q13873
Specificity
Detects human BMPR-II in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) BMPR‑IA, recombinant mouse (rm) BMPR-IA, rhBMPR-IB, and rmBMPR-IB is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
BMPR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunohistochemistry 5-15 ug/mL
  • CyTOF-ready
Publications
Read Publications using
AF811 in the following applications:

  • 1 publication
  • ICC
    1 publication
  • IHC
    2 publications
  • WB
    3 publications

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMPR-II Antibody

  • BMP type II receptor
  • BMP type-2 receptor
  • BMPR2
  • BMPR-2
  • BMPR3
  • BMPRII
  • BMPR-II
  • BMPR-IIprimary pulmonary hypertension 1
  • Bone morphogenetic protein receptor type II
  • bone morphogenetic protein receptor type-2
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • BRK-3
  • EC 2.7.11
  • EC 2.7.11.30
  • FLJ41585
  • FLJ76945
  • PPH1BMR2
  • T-ALK
  • type II activin receptor-like kinase
  • type II receptor for bone morphogenetic protein-4

Background

Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signal transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II, and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4, and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity (1-3).

  1. Rosenzweig, B.L. et al. (1995) Proc. Natl. Acad. Sci. USA 92:7632.
  2. Beppu, H. et al. (1997) Biochem. Biophys. Res. Commun. 235:499.
  3. Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BMPR-II Antibody (AF811)(7)

We have publications tested in 3 confirmed species: Human, Mouse, Rabbit.

We have publications tested in 4 applications: Flow, ICC, IHC, WB.


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Flow
(1)
ICC
(1)
IHC
(2)
WB
(3)
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Human
(5)
Mouse
(1)
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(1)
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Showing Publications 1 - 7 of 7.
Publications using AF811 Applications Species
SV Hegarty, AM Sullivan, GW O'Keeffe Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth Neurosci. Lett, 2017;643(0):32-37. 2017 [PMID: 28188849] (ICC,, Human) ICC Human
Wang Y, Kahaleh B Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. J Cell Mol Med, 2013;17(10):1291-9. 2013 [PMID: 23859708] (WB,, Human) WB Human
Chou H, Lai D, Huang C, McLennan I, Wang H, Wang P BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro. PLoS ONE, 2013;8(3):e58441. 2013 [PMID: 23472198] (IHC,, Mouse) IHC Mouse
Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, Roux S Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro. Cell Signal, 2013;25(4):717-28. 2013 [PMID: 23313128] (WB,, Human) WB Human
He J, Dong J, Wang T Bone morphogenetic protein receptor IB as a marker for enrichment of osteogenic precursor-like cells in human dermis. Arch. Dermatol. Res., 2011;303(8):581-90. 2011 [PMID: 21644047] (Flow,, Human) Flow Human
Yao Y, Shao ES, Jumabay M, Shahbazian A, Ji S, Bostrom KI High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler. Thromb. Vasc. Biol., 2008;28(12):2266-74. 2008 [PMID: 18948634] (WB,, Human) WB Human
Tcacencu I, Carlsoo B, Stierna P Cell origin in experimental repair of cricoid cartilage defects treated with recombinant human bone morphogenetic protein-2. Wound Repair Regen, 2005;13(3):341-9. 2005 [PMID: 15953055] (IHC,, Rabbit) IHC Rabbit

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Bioinformatics

Gene Symbol BMPR2
Entrez
Uniprot