PC‑3 human prostate cancer cell line was stained with Goat Anti-Human BMPR‑II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF811, filled histogram) or control antibody (Catalog # AB-108-C, open ...read more
BMPR-II was detected in formalin fixed paraffin-embedded sections of human prostate using Goat Anti-Human BMPR-II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF811) at 15 µg/mL overnight at 4 °C. Tissue ...read more
Mouse myeloma cell line NS0-derived recombinant human BMPR-II Ala26-Ile151 Accession # Q13873
Detects human BMPR-II in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) BMPR‑IA, recombinant mouse (rm) BMPR-IA, rhBMPR-IB, and rmBMPR-IB is observed.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Immunogen affinity purified
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for BMPR-II Antibody
BMP type II receptor
BMP type-2 receptor
BMPR-IIprimary pulmonary hypertension 1
Bone morphogenetic protein receptor type II
bone morphogenetic protein receptor type-2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
type II activin receptor-like kinase
type II receptor for bone morphogenetic protein-4
Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signal transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II, and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4, and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity (1-3).
Rosenzweig, B.L. et al. (1995) Proc. Natl. Acad. Sci. USA 92:7632.
Beppu, H. et al. (1997) Biochem. Biophys. Res. Commun. 235:499.
Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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