5-HT1D Antibody


Western Blot: 5-HT1D Antibody [NB100-56349] - Analysis of 5-HT1DR in brain lysate with anti-5-HT1DR pcAb. A protein band of approximate molecular weight of 40 kDa was detected.
Simple Western: 5-HT1D Antibody [NB100-56349] - Simple Western lane view shows a specific band for 5HT1D in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa ...read more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, Simple Western
0.5 mg/ml

Order Details

5-HT1D Antibody Summary

This antibody was generated by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 1-18 and 251-267 of rat 5-HT1DR (Genbank accession no. NP_036984).
Protein G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.05% BSA
0.05% Sodium Azide
0.5 mg/ml
Protein G purified


Application Notes
In Simple Western only 10-15 uL of the recommended dilution is used per data point. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
42 kDa
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NB100-56349 in the following applications:

  • WB
    1 publication

Alternate Names for 5-HT1D Antibody

  • 5HT1D
  • 5-HT-1D
  • 5-HT-1D-alpha
  • 5-HT1DHTR1DA
  • 5-hydroxytryptamine (serotonin) receptor 1D
  • HT1DA
  • HTR1D
  • HTR1DA
  • HTRL
  • RDC4
  • RDC4,5-hydroxytryptamine receptor 1D
  • Serotonin receptor 1D


Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. The 5-HT1D (formerly known as 5-HT1Da) receptor has 63% overall structural homology with the 5-HT1B receptor and a 77% amino acid sequence homology in the seven transmembrane domains. In situ hybridization studies have detected highest level of mRNA in primary olfactory cortex, accumbens nucleus, caudate putamen, lateral mammilary nucleus and medial vestibular nucleus. The presence of relatively high levels of 5-HT1D mRNA in the locus coeruleus suggest that, when expressed on nerve terminals, this receptor could modulate the release of catecholamines. The 5-HT1D receptor may function as an autoreceptor. Like 5-HT1B receptors, 5-HT1D receptors also appear to act as heteroreceptors. Acting on the 5-HT1D receptors, 5-HT appears to inhibit release of glutamate from rat cerebellar synaptosomes and acetylcholine from guinea pig hippocampal synaptosomes. It has been suggested that neurogenic inflammation and nociceptive activity within trigemino- vascular afferents. Endothelium-dependent relaxation in the pig coronary artery has been claimed to be mediated by 5-HT1D receptors. Like other members of the 5-HT1 family, 5-HT1D receptors are negatively coupled to adenylate cyclase.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for 5-HT1D Antibody (NB100-56349)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.

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Positive Control Lysate(s)

Secondary Antibodies


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Contact Information

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Gene Symbol HTR1D

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