5-HT1D Products

Antibodies
5-HT1D Antibody
5-HT1D Antibody
NB100-56349
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Rabbit Polyclonal
5-HT1D Antibody
5-HT1D Antibody
NLS577
Species: Hu, Mk, Pm, Bovine, Chicken, Equine, Guinea Pig, Mouse, Porcine, Rabbit, Rat, Bat, Turkey
Applications: IHC-P
Host: Rabbit Polyclonal
5-HT1D Antibody
5-HT1D Antibody
NLS589
Species: Hu, Po, Bovine, Canine, Equine, Guinea Pig, Primate, Rabbit, Bat, Monkey
Applications: IHC-P
Host: Rabbit Polyclonal
Proteins
5-HT1D Recombinant Protein
5-HT1D Recombinant Protein
H00003352-P01
Species: Hu
Applications: WB, ELISA, PA
5-HT1D Recombinant Protein
5-HT1D Recombinant Protein
H00003352-G01
Species: Hu
RNAi
5-HT1D RNAi
5-HT1D RNAi
H00003352-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1,2). The 5-HT1D (formerly known as 5-HT1Da) receptor has 63% overall structural homology with the 5-HT1B receptor and a 77% amino acid sequence homology in the seven transmembrane domains (3). In situ hybridization studies have detected highest level of mRNA in primary olfactory cortex, accumbens nucleus, caudate putamen, lateral mammilary nucleus and medial vestibular nucleus (4). The presence of relatively high levels of 5-HT1D mRNA in the locus coeruleus suggest that, when expressed on nerve terminals, this receptor could modulate the release of catecholamines. The 5-HT1D receptor may function as an autoreceptor. Like 5-HT1B receptors, 5-HT1D receptors also appear to act as heteroreceptors. Acting on the 5-HT1D receptors, 5-HT appears to inhibit release of glutamate from rat cerebellar synaptosomes and acetylcholine from guinea pig hippocampal synaptosomes (5). It has been suggested that neurogenic inflammation and nociceptive activity within trigemino- vascular afferents. Endothelium-dependent relaxation in the pig coronary artery has been claimed to be mediated by 5-HT1D receptors (6). Like other members of the 5-HT1 family, 5-HT1D receptors are negatively coupled to adenylate cyclase.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Rat
Product By Gene ID 3352
Alternate Names
  • 5-HT-1D
  • Serotonin receptor 1D
  • RDC4,5-hydroxytryptamine receptor 1D
  • HTRL
  • HT1DA
  • 5-HT1DHTR1DA
  • 5-HT-1D-alpha
  • 5-hydroxytryptamine (serotonin) receptor 1D

Pathways for 5-HT1D

View related products by pathway and learn more about each of the pathways below.

Response To Risperidone
Cell Proliferation
Parturition

Research Areas for 5-HT1D

Find related products by research area and learn more about each of the different research areas below.

GPCR

Bioinformatics Tool for 5-HT1D

Discover related pathways, diseases and genes to 5-HT1D. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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