Novus Biologicals launches a new LOX propeptide antibody

Novus Biologicals carries an extensive line of LOX and LOPP antibodies.   A recent addition to this group of antibodies is a new anti-LOX Propeptide antibody (catalog number NBP1-30327).  This rabbit polyclonal antibody was made to an internal region of the human protein within amino acid residues 118-168.  This antibody is unique and especially useful, as it recognizes the glycosylated propeptide form (~35 kDa), as well as the proenzyme form (~50 kDa).  NBP1-30327 was QC tested in Western blot on MDA-MB-231, a human cancer cell lysate, and is also reactive with rat.

LOX Propeptide Antibody Image

Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. It is synthesized as a 50 kDa precursor, which is secreted into the extracellular matrix and subsequently proteolytically processed into a 30 kDa active enzyme, as well as an 18 kDa propeptide. As mentioned above, Novus' new antibody recognizes the precursor as well as the processed enzyme.  LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.





For more information on this new LOX Propeptide antibody or to inquire about product collaborations, please contact the Novus Product Development Team by calling 303-730-1950 or via e-mail at

Release Date: 
Monday, March 1, 2010 - 07:00