LDLR Antibody (EP1553Y)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ELISA, ICC/IF, WB.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using NB110-57162	Applications	Species
Hu PA, Chen CH, Guo BC et al. Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice Nutrients 2020-05-18 [PMID: 32443556]
Picard C, Poirier A, Belanger S et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer's disease: A genetic and proteomic multi-cohort study PLoS ONE 2019-08-22 [PMID: 31437157] (ELISA, Human)	ELISA	Human
Pennanen P, Syvala H, Blauer M et al. The effects of metformin and simvastatin on the growth of LNCaP and RWPE-1 prostate epithelial cell lines. Eur. J. Pharmacol. 2016-06-21 [PMID: 27341997]
Pincon A, Coulombe JD, Chouinard-Watkins R, Plourde M Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. J Nutr Biochem. 2016-08-01 [PMID: 27239755] (WB, Mouse)	WB	Mouse
Rideout TC, Carrier B, Wen S et al. Complementary Cholesterol-Lowering Response of a Phytosterol/alpha-Lipoic Acid Combination in Obese Zucker Rats J Diet Suppl. 2015-02-09 [PMID: 25664679] (WB, Rat)	WB	Rat
Krueger WH, Tanasijevic B, Barber V et al. Cholesterol-Secreting and Statin-Responsive Hepatocytes from Human ES and iPS Cells to Model Hepatic Involvement in Cardiovascular Health. PLoS One 2013-07-11 [PMID: 23874411] (ICC/IF, Human)	ICC/IF	Human
Wen S, Jadhav KS, Williamson DL, Rideout TC. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. J Lipids 2013-01-01 [PMID: 23862065] (WB, Mouse)	WB	Mouse
Kim WS, Li H, Ruberu K et al. Deletion of Abca7 Increases Cerebral Amyloid-beta Accumulation in the J20 Mouse Model of Alzheimer's Disease. J Neurosci. 2013-03-06 [PMID: 23467355]
Garbarino J, Pan M, Chin HF et al. STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC J Lipid Res 2012-12-01 [PMID: 23033213]
Wei J, Ching LC, Zhao JF et al. Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis. Acta Physiol (Oxf) 2013-02-01 [PMID: 23025809] (WB, Mouse)	WB	Mouse
Murtola TJ, Syvala H, Pennanen P et al. The Importance of LDL and Cholesterol Metabolism for Prostate Epithelial Cell Growth PLoS One 2012-01-01 [PMID: 22761797] (WB, Human)	WB	Human
Basak JM, Verghese PB, Yoon H, Kim J, Holtzman DM. Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of A Beta Uptake and Degradation by Astrocytes. J Biol Chem;287(17):13959-71. 2012-04-20 [PMID: 22383525] (WB, Mouse)	WB	Mouse
Domenger D, Dea D, Theroux L et al. The MPTP neurotoxic lesion model of Parkinson’s disease activates the apolipoprotein E cascade in the mouse brain. Experimental Neurology. 2011-01-01 [PMID: 22155743]
Kolmakova A, Wang J, Brogan R et al. Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. Endocrinology 2010-11-01 [PMID: 20844007] (WB, Human)	WB	Human
Bogan RL, Hennebold JD. The reverse cholesterol transport system as a potential mediator of luteolysis in the primate corpus luteum. Reproduction 2010-01-01 [PMID: 19776099]
Wahrle SE, Jiang H, Parsadanian M et al. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest 2008-02-01 [PMID: 18202749] (Mouse)		Mouse
Show All 16 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Other	07/30/2009	View Summary Application Western Blot Sample Tested cell lines (Hep2 HepG2), Sample Amount: 50ug Species Other Lot YD112703

Array NB110-57162

• LDLR Antibodies
• LDLR Antibody Pair
• LDLR ELISA Kit
• LDLR Lysate
• LDLR Proteins
• LDLR Proteins and Enzymes
• LDLR ELISAs