Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Preservative
No Preservative
Purity
Immunogen affinity purified
Notes
Manufactured by SDIX's proprietary Genomic Antibody Technology. GAT FAQs.
Alternate Names for ITM2C Antibody
BRI3
BRI3E25C
BRICD2C
BRICHOS domain containing 2C
Cerebral protein 14
E25
hRPC.1050_D_4
integral membrane protein 2C
integral membrane protein 3
ITM2C
ITM3
Transmembrane protein BRI3
Background
ITM2C is a negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. ITM2C may also play a role in TNF-induced cell death and neuronal differentiation By similarity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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