AIF Antibody (E20)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

AIF, or apoptosis-inducing factor, is a flavoprotein localized to the mitochondrial membrane that plays a primary role in caspase-independent cell death, or apoptosis (1,2). AIF translocates to the nucleus when apoptosis is induced and causes mitochondria to release the apoptogenic proteins, cytochrome c and caspase-9. Apoptotic activity of AIF leads to chromatin condensation and DNA fragmentation (1). Similar to cytochrome c, AIF is a bifunctional protein with an oxidoreductase function and a second apoptogenic function. In contrast to cytochrome c, however, AIF acts in a caspase-independent fashion (2,3,4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 applications: ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 10.

Publications using NB110-55446	Applications	Species
Huang R, Chen XQ, Huang Y et al. The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells. Asian J Androl 2010-07-01 [PMID: 20473320]
Saito C, Lemasters JJ, Jaeschke H et al. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 2010-07-01 [PMID: 20423716] (WB)	WB
Chen X, Gong J, Zeng H et al. MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. Cancer Res 2010-04-01 [PMID: 20332243]
Shen H, Hu X, Liu C et al. Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiol Dis 2010-03-01 [PMID: 20026271] (WB)	WB
Lin CY, Wu HY, Wang PL et al. Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway. Int J Biochem Cell Biol 2010-01-01 [PMID: 19782762] (WB)	WB
Ishimura R, Martin GR, Ackerman SL et al. Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J Neurosci 2008-05-01 [PMID: 18463247] (IF/IHC)	IF/IHC
Bajt ML, Farhood A, Lemasters JJ et al. Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther 2008-01-01 [PMID: 17906064] (WB)	WB
Cao G, Xing J, Xiao X et al. Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury. J Neurosci 2007-08-01 [PMID: 17728442] (WB)	WB
Yu SW, Andrabi SA, Wang H et al. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A 2006-11-01 [PMID: 17116881] (ICC/IF)	ICC/IF
Bajt ML, Cover C, Lemasters JJ et al. Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 2006-11-01 [PMID: 16896059] (IF/IHC)	IF/IHC

Array NB110-55446

• AIF Antibodies
• AIF ELISA Kit
• AIF Lysates
• AIF Proteins