AIF Products

Description

AIF, or apoptosis-inducing factor, is a flavoprotein localized to the mitochondrial membrane that plays a primary role in caspase-independent cell death, or apoptosis (1,2). AIF translocates to the nucleus when apoptosis is induced and causes mitochondria to release the apoptogenic proteins, cytochrome c and caspase-9. Apoptotic activity of AIF leads to chromatin condensation and DNA fragmentation (1). Similar to cytochrome c, AIF is a bifunctional protein with an oxidoreductase function and a second apoptogenic function. In contrast to cytochrome c, however, AIF acts in a caspase-independent fashion (2,3,4).

Bioinformatics

Entrez	11629 Mouse 26926 Mouse 29427 Rat 83533 Rat 9131 Human
Uniprot	NP_004199 Human NP_004199.1 Human O95381 Human O95831 Human O95831-2 Human
Product By Gene ID	9131
Alternate Names	AIFapoptosis-inducing factor 1, mitochondrial apoptosis-inducing factor, mitochondrion-associated, 1 COXPD6 MGC111425 PDCD8striatal apoptosis-inducing factor programmed cell death 8 (apoptosis-inducing factor) Programmed cell death protein 8

Research Areas for AIF

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Cell Cycle and Replication
Chromatin Research
Mitochondrial Markers
Tumor Suppressors