ZMYM1 Antibody - BSA Free

Western Blot: ZMYM1 Antibody [NBP1-76523] - Rat lung tissue lysate with ZMYM1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry: ZMYM1 Antibody - BSA Free [NBP1-76523] - Immunohistochemistry of ZMYM1 in rat lung tissue with ZMYM1 antibody at 5 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

ZMYM1 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZMYM1 . The immunogen is located within amino acids 990 - 1040 of ZMYM1. Amino Acid Squence: WNEPLNETTAKHVQEFY
• Specificity: At least two isoforms of ZMYM1 are known to exist; this antibody will detect only the shorter isoform. ZMYM1 antibody is predicted to not cross-react with other ZMYM protein family members.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ZMYM1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1 ug/ml
• Control Peptide:

  ZMYM1 Peptide (NBP1-76523PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for ZMYM1 Antibody - BSA Free

• FLJ23151
• zinc finger, MYM domain containing 1
• zinc finger, MYM-type 1

Background

Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ZMYM1 Antibody (NBP1-76523)(1)

Publication using NBP1-76523

• Lee D, Apelt K, Lee SO et al. ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination Nucleic acids research 2022-03-07 [PMID: 35253893] (WB, Human)

Bioinformatics

• Gene Symbol: ZMYM1
• Uniprot:
  • NP_079048(Human)