ZMIZ1/Zimp10 Antibody [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor Plus 594

ZMIZ1/Zimp10 Antibody [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human ZMIZ1/Zimp10 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ZMIZ1/Zimp10 Antibody [Alexa Fluor™ Plus 594]

• FLJ13541
• hZIMP10
• KIAA1224
• KIAA1224Zimp10
• MIZ
• PIAS-like protein Zimp10
• RAI17
• RAI17TRAFIP10
• retinoic acid induced 17
• Retinoic acid-induced protein 17
• RP11-519K18.1
• TRAFIP10
• Zimp10
• ZIMP10FLJ00092 protein
• zinc finger MIZ domain-containing protein 1
• zinc finger, MIZ-type containing 1
• zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
• ZMIZ1

Background

Human ZMIZ1 (zinc finger and Miz-domain containing 1), previously called Zimp10 (zinc finger, Miz1, PIAS-like protein on chromosome 10) is a 1067 amino acid (aa), approximately 130 kDa cytoplasmic and nuclear protein. It is a coactivator of the androgen receptor (AR), and enhances AR-mediated transcription and AR sumoylation. It also coactivates other transcription factors such as SMAD4 and p53. It is normally expressed in human ovary, testis and prostate epithelial cells. The ZIMZ1 gene can be fused to ABL1 in a B-cell acute lymphocytic leukemia. Within the region used as an immunogen, human ZMIZ1 shares 98% and 97% aa sequence identity with mouse and rat ZMIZ1, respectively. A 997 aa isoform with an alternate sequence replacing aa 1-94 has been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.