XPB Products

Description

ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.

Bioinformatics

Entrez	13872 Mouse 2071 Human
Uniprot	AAH08820 Human NM_000122 Human NP_000113.1 Human
Product By Gene ID	2071
Alternate Names	Basic transcription factor 2 89 kDa subunit BTF2 p89 BTF2 DNA excision repair protein ERCC-3 DNA repair protein complementing XP-B cells EC 3.6.1 EC 3.6.4.12 excision repair cross-complementing rodent repair deficiency, complementationgroup 3 (xeroderma pigmentosum group B complementing) GTF2H RAD25 TFIIH basal transcription factor complex 89 kDa subunit TFIIH basal transcription factor complex helicase XPB subunit TFIIH p89 TFIIH Xeroderma pigmentosum group B-complementing protein xeroderma pigmentosum, complementation group B XPBC XPBTFIIH 89 kDa subunit

Research Areas for XPB

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Nucleotide Excision Repair