XPA Antibody

Product Discontinued

XPA Antibody Summary

• Immunogen: Recombinant full length protein (Human).
• Localization: Nuclear
• Specificity: recognises both normal and recombinant XPA, and shows no cross reactivity with other XP proteins.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: XPA
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:5000
• Application Notes: IHC-P: Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Use of antigen unmasking fluid for this purpose is recommended. WB: Detects a band of approximately 40-42 kDa doubled (predicted molecular weight: 32.8 kDa).
• Control:

  XPA Overexpression Lysate

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: 0.09% Sodium Azide
• Purity: Unpurified

Alternate Names for XPA Antibody

• DNA repair protein complementing XP-A cells
• excision repair-controlling
• Xeroderma pigmentosum group A-complementing protein
• xeroderma pigmentosum, complementation group A
• XP1
• XPA
• XPACXP1

Background

XPA encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: XPA
• Entrez:
  • 7507(Human)